Nađa Nikolić

  1. Viši naučni saradnik na Stomatološkom fakultetu Univerziteta u Beogradu, sa više od 70 naučnih radova objavljenih u domaćim i međunarodnim časopisima. Učestvovala je u brojnim projektima iz oblasti imunologije, genetike i biomedicine.

    U slobodno vreme, kao stručni saradnik Mangrowe tima, doprinosi razvoju i naučnoj validaciji bioloških transformacionih programa, sa posebnim fokusom na personalizovanu suplementaciju, regeneraciju i povezivanje savremene nauke sa svakodnevnom praksom.


    STRUČNA BIOGRAFIJA


    Dr Nađa Nikolić rođena je 6. decembra 1983. godine u Beogradu. Studije je započela 2002. godine na Biološkom fakultetu Univerziteta u Beogradu, studijska grupa Molekularna biologija i fiziologija, a diplomirala je 2009. godine. Doktorske akademske studije na Biološkom fakultetu Univerziteta u Beogradu, Modul Genetika, započela je 2010. godine. Doktorsku disertaciju pod nazivom „Genetička i epigenetska studija pleomorfnih adenoma pljuvačnih žlezda čoveka: mutacioni status HER-2, c-myc, H-ras i TP53 gena i metilacioni status p14 i p16 gena” odbranila je 11.03.2016. godine. 

    Od 2011. zaposlena kao istraživač-pripravnik, od 2013. godine kao istraživač saradnik, od aprila 2018. kao naučni saradnik, a od februara 2023. kao viši naučni saradnik na Stomatološkom fakultetu Univerziteta u Beogradu. 

    U skladu sa Uredbom o normativima i standardima raspodele sredstava akreditovanim naučnoistraživačkim organizacijama („Службени гласник РС“, бр. 90/2019, 96/2023, 110/2023 и 16/2024) od marta 2024. rangirana među 10% izvrsnih istraživača u oblasti Prirodno-matematičke i medicinske nauke.

    •  

    Naučnoistraživački projekti

    • Član tima na bilateralnom projektu naučne i tehnološke saradnje između Republike Srbije i Republike Francuske u okviru Programa „PAVLE SAVIĆ“ (2020–2021): „Ciljanje raznolikosti mikrobiote kod apikalnog parodontitisa“.

    • Član tima na projektu u okviru izvršnog programa naučne i tehnološke saradnje između Republike Srbije i Italijanske Republike (2016–2018, „Grande Rilevanza“): „Inovativna terapija za agresivne tumore glave i vrata“.

    • Član tima na projektu Ministarstva prosvete, nauke i tehnološkog razvoja Republike Srbije: „Genetska kontrola i molekularni mehanizmi uključeni u maligne, inflamatorne i razvojne patologije orofacijalne regije“, sprovedenom u Laboratoriji za bazična istraživanja Stomatološkog fakulteta Univerziteta u Beogradu (2011-2019).

    • Član tima i koordinator radnog paketa na projektu Fonda za nauku Republike Srbije, br. 7750038: „Oralni karcinom – novi pristupi u prevenciji, kontroli i postoperativnoj regeneraciji – in vitro studija (ORCA-PCR)”, sproveden u Laboratoriji za molekularnu biologiju Centra za istraživanje implantata Stomatološkog fakulteta Univerziteta u Beogradu (2022-2025).

    Od 2012. do 2015. godine, kao i školske 2020/21. godine učestvovala je u izvođenju praktične nastave u okviru Katedre za genetiku Stomatološkog fakulteta Univerziteta u Beogradu. Bila je član sekretarijata Petog kongresa Društva genetičara Srbije (28.9.-10.10.2014.), kao i Organizacionog odbora Devetog Balkanskog kongresa humane genetike (17-20. septembar 2015.) i Organizacionog odbora Šestog kongresa Društva genetičara Srbije (održanog od 13-17. oktobra 2019. godine) i predsednik Organizacionog odbora Sedmog kongresa Društva genetičara Srbije  (održanog od 02-05. oktobra 2024. godine). Član je Društva genetičara Srbije od 2011. godine i Srpskog društva za molekularnu biologiju od 2017. godine.


    Nađa Nikolić je autor i koautor 75 naučnih publikacija na SCI listi, citiranih preko 900 puta, i preko 45 saopštenja na međunarodnim naučnim skupovima.


    ORCID: https://orcid.org/0000-0002-8513-9313

    Naučni članci publikovani u poslednjih pet godina: 

    1. Susa A, Davidovic D, Nikolic N, Sljivancanin Jakovljevic T, Kujundzic V, Mihajlovic S, Bogdanovic L. The Role of Air Pollution Exposure and GSTM1-/GSTT1-Null Genotypes in Gestational Diabetes Mellitus Development: A Case-Control Study on Gene-Environment Interactions. Antioxidants (Basel). 2025 May 28;14(6):652. doi: 10.3390/antiox14060652. PMID: 40563287; PMCID: PMC12189565.
    2. Toljic M., Joksic I., Nikolic N., Carkic J., Milasin J., Munjas J., Karadzov Orlic N. Expression analysis of microRNAs and cytokine mRNAs in pregnancies complicated by gestational hypertension. (2024) European Journal of Obstetrics and Gynecology and Reproductive Biology, 301, pp. 64 – 69. DOI: 10.1016/j.ejogrb.2024.07.069
    3. Carkic J., Nikolic N., Sango V., Riberti N., Anicic B., Milasin J. MiR-26a and miR-191 are upregulated while PLAG1 and HIF2 are downregulated in pleomorphic adenomas of the salivary glands compared to Warthin tumors. (2024) Journal of Oral Pathology and Medicine, 53 (7), pp. 451 – 457. DOI: 10.1111/jop.13565
    4. Toljic, M., Nikolic, N., Joksic, I., Carkic, J., Munjas, J., Karadzov Orlic, N., Milasin, J. Expression of miRNAs and proinflammatory cytokines in pregnant women with gestational diabetes mellitus. (2024) Journal of Reproductive Immunology, 162, art. no. 104211. DOI: 10.1016/j.jri.2024.104211
    5. Jakovljevic, A., Nikolic, N., Paternò Holtzman, L., Tournier, P., Gaudin, A., Cordaro, L., Milinkovic, I. Involvement of the Notch signaling system in alveolar bone resorption (2023) Japanese Dental Science Review, 59, pp. 38-47.  DOI: 10.1016/j.jdsr.2023.02.003
    6. Tomic, U., Nikolic, N., Carkic, J., Mihailovic, D., Jelovac, D., Milasin, J., Pucar, A. Streptococcus mitis and Prevotella melaninogenica Influence Gene Expression Changes in Oral Mucosal Lesions in Periodontitis Patients (2023) Pathogens, 12 (10), art. no. 1194. DOI: 10.3390/pathogens12101194
    7. Jezdic, M., Nikolic, N., Krasavcevic, A.D., Milasin, J., Aleksic, Z., Carkic, J., Jankovic, S., Milinkovic, I. Clinical, microbiological and osteoimmunological findings in different peri-implant conditions – A cross-sectional study (2023) Clinical Oral Implants Research, 34 (9), pp. 958-966. DOI: 10.1111/clr.14122
    8. Pierfelice, T.V., Lazarevic, M., Mitic, D., Nikolic, N., Radunovic, M., Iezzi, G., Piattelli, A., Milasin, J. Red Light and 5% Aminolaevulinic Acid (5%) Inhibit Proliferation and Migration of Dysplastic Oral Keratinocytes via ROS Production: An In Vitro Study (2023) Gels, 9 (8), art. no. 604. DOI: 10.3390/gels9080604
    9. Baldan, F., Gnan, C., Lazarevic, M., Nikolic, N., Mio, C., Tepavcevic, Z., Robiony, M., Milasin, J., Damante, G. Somatic genomic imbalances in ‘tumour-free’ surgical margins of oral cancer (2023) International Journal of Oral and Maxillofacial Surgery, 52 (8), pp. 831-838. DOI: 10.1016/j.ijom.2022.12.008
    10. Djinic Krasavcevic, A., Nikolic, N., Milinkovic, I., Carkic, J., Jezdic, M., Jankovic, S., Aleksic, Z., Milasin, J. Notch signalling cascade and proinflammatory mediators in peri-implant lesions with different RANKL/OPG ratios—An observational study (2023) Journal of Periodontal Research, 58 (2), pp. 360-368. DOI: 10.1111/jre.13096
    11. Jaksic Karisik, M., Lazarevic, M., Mitic, D., Nikolic, N., Milosevic Markovic, M., Jelovac, D., Milasin, J. Osteogenic and Adipogenic Differentiation Potential of Oral Cancer Stem Cells May Offer New Treatment Modalities (2023) International Journal of Molecular Sciences, 24 (5), art. no. 4704. DOI: 10.3390/ijms24054704
    12. Jurisic, V., Obradovic, J., Nikolic, N., Javorac, J., Perin, B., Milasin, J. Analyses of P16INK4a gene promoter methylation relative to molecular, demographic and clinical parameters characteristics in non-small cell lung cancer patients: A pilot study (2023) Molecular Biology Reports, 50 (2), pp. 971-979.  DOI: 10.1007/s11033-022-07982-1
    13. Jovanović, M., Kostić, M., Đorđević, N.S., Ilić, A., Tomić, U., Nikolić, N., Kesić, L.J., Gligorijević, N., Igić, M., Jovanović, R., Đerlek, A., Stojanović, S., Milašin, J. The influence of the tooth preparation finish line position on the expression of matrix metalloproteinase-9 and the presence of periodontopathogens in the gingival crevicular fluid (2023) European Review for Medical and Pharmacological Sciences, 27 (17), pp. 8026-8038.  DOI: 10.26355/eurrev_202309_33564
    14. Milosevic, O., Nikolic, N., Carkic, J., Juloski, J., Vucic, L., Glisic, B., Milasin, J. Single nucleotide polymorphisms MYO1H 1001 C>T SNP (rs3825393) is a strong risk factor for mandibular prognathism (2022) American Journal of Orthodontics and Dentofacial Orthopedics, 162 (5), pp. e246-e251. DOI: 10.1016/j.ajodo.2021.09.016
    15. Sljivancanin Jakovljevic, T., Martic, J., Jacimovic, J., Nikolic, N., Milasin, J., Mitrović, T.L. Association between innate immunity gene polymorphisms and neonatal sepsis development: a systematic review and meta-analysis (2022) World Journal of Pediatrics, 18 (10), pp. 654-670. DOI: 10.1007/s12519-022-00569-7
    16. Andric, M., Jacimovic, J., Jakovljevic, A., Nikolic, N., Milasin, J. Gene polymorphisms in odontogenic keratocysts and ameloblastomas: A systematic review (2022) Oral Diseases, 28 (6), pp. 1421-1430. DOI: 10.1111/odi.13865
    17. Jakovljevic, A., Jacimovic, J., Georgiou, A.C., Nikolic, N., Aminoshariae, A., van der Waal, S.V., Nagendrababu, V. Single nucleotide polymorphisms as a predisposing factor for the development of apical periodontitis—An umbrella review (2022) International Endodontic Journal, 55 (7), pp. 700-713. DOI: 10.1111/iej.13756
    18. Milosevic, O., Nikolic, N., Carkic, J., Majstorović, N., Glisic, B., Milasin, J. ANALYSIS OF COL1A1 AND MMP9 SINGLE NUCLEOTIDE POLYMORPHISMS IN MANDIBULAR PROGNATHISM (2022) Genetika, 54 (2), pp. 777-786. DOI: 10.2298/GENSR2202777M
    19. Jovanovic, K., Carkic, J., Nikolic, N., Novakovic, N., Hadzi-Mihailovic, M., Colak, E., Cakic, S., Milasin, J. DETECTION AND QUANTIFICATION OF PATHOGENIC MICROORGANISMS IN PATIENTS WITH CHRONIC PERIODONTITIS BEFORE AND AFTER TREATMENT WITH CHLORHEXIDINE DIGLUCONATE (2022) Genetika, 54 (1), pp. 491-498. DOI: 10.2298/GENSR2201491J
    20. Nikolic, N., Carkic, J., Jacimovic, J., Jakovljevic, A., Anicic, B., Jezdic, Z., Milasin, J. Methylation of tumour suppressor genes in benign and malignant salivary gland tumours: a systematic review and meta-analysis (2022) Epigenetics, 17 (12), pp. 1661-1676. DOI: 10.1080/15592294.2022.2052426
    21. Zivanovic, S., Papic, M., Vucicevic, T., Miletic Kovacevic, M., Jovicic, N., Nikolic, N., Milasin, J., Paunovic, V., Trajkovic, V., Mitrovic, S., Lukic, M.L., Lukic, A., Ljujic, B. Periapical lesions in two inbred strains of rats differing in immunological reactivity (2022) International Endodontic Journal, 55 (1), pp. 64-78. DOI: 10.1111/iej.13638
    22. Milinkovic, I., Djinic Krasavcevic, A., Nikolic, N., Aleksic, Z., Carkic, J., Jezdic, M., Jankovic, S., Milasin, J. Notch down-regulation and inflammatory cytokines and RANKL overexpression involvement in peri-implant mucositis and peri-implantitis: A cross-sectional study (2021) Clinical Oral Implants Research, 32 (12), pp. 1496-1505. DOI: 10.1111/clr.13850
    23. Sljivancanin Jakovljevic, T., Kontic-Vucinic, O., Nikolic, N., Carkic, J., Stamenkovic, J., Soldatovic, I., Milasin, J. Association Between Endothelial Nitric Oxide Synthase (eNOS) −786 T/C and 27-bp VNTR 4b/a Polymorphisms and Preeclampsia Development (2021) Reproductive Sciences, 28 (12), pp. 3529-3539. DOI: 10.1007/s43032-021-00632-0
    24. Jakovljevic, A., Nikolic, N., Jacimovic, J., Miletic, M., Andric, M., Milasin, J., Aminoshariae, A., Azarpazhooh, A. Tumor Necrosis Factor Alpha −308 G/A Single-Nucleotide Polymorphism and Apical Periodontitis: An Updated Systematic Review and Meta-analysis (2021) Journal of Endodontics, 47 (7), pp. 1061-1069. DOI: 10.1016/j.joen.2021.03.007
    25. Grubisa, I., Jankovic, M., Nikolic, N., Jaksic, V., Risimic, D., Mavija, M., Stamenkovic, M., Zlatovic, M., Milasin, J. Novel TEAD1 gene variant in a Serbian family with Sveinsson’s chorioretinal atrophy (2021) Experimental Eye Research, 207, art. no. 108575. DOI: 10.1016/j.exer.2021.108575
    26. Mirnić, J., Đurić, M., Nikolić, N., Veljović, T., Gušić, I., Petrović, Đ., Milašin, J. CLINICAL AND MICROBIOLOGICAL ASSESSMENT OF NON-SURGICAL TREATMENT OF CHRONIC PERIODONTITIS IN CONTROLLED AND UNCONTROLLED TYPE 2 DIABETIC PATIENTS (2021) Acta Clinica Croatica, 60 (3), pp. 406-414. DOI: 10.20471/acc.2021.60.03.10
    27. Milinkovic, I., Mijailovic, I., Markovic, A., Janjic, B., Nikolic, N., Milasin, J., Milicic, B., Aleksic, Z., Vasovic, D. Adjunctive application of systemic antibiotics in non-surgical aggressive periodontitis treatment: Clinical and microbiological findings (2021) Open Access Macedonian Journal of Medical Sciences, 9 (D), pp. 149-154. DOI: 10.3889/oamjms.2021.6855
    28. Anicic, B., Nikolic, N., Carkic, J., Jelovac, D., Jezdic, Z., Dozic, B., Danilovic, V., Milasin, J.Matrix metalloproteinase 7 (MMP-7) and tissue inhibitor of metalloproteinases-2 (timp-2) downregulation complements plag1 oncogene overexpression in pleomorphic adenoma pathogenesis (2021) Genetika, 53 (1), pp. 339-348. DOI: 10.2298/GENSR2101339A
    29. Djinic Krasavcevic, A., Nikolic, N., Mijailovic, I., Carkic, J., Milinkovic, I., Jankovic, S., Aleksic, Z., Milasin, J. Impact of Notch signalling molecules and bone resorption regulators on clinical parameters in periodontitis (2021) Journal of Periodontal Research, 56 (1), pp. 131-138. DOI: 10.1111/jre.12801
    30. Petrovic, S.M., Nikolic, N., Toljic, B., Arambasic-Jovanovic, J., Milicic, B., Milicic, T., Jotic, A., Vidakovic, M., Milasin, J., Pucar, A. The association of tumor necrosis factor alpha, lymphotoxin alpha, tumor necrosis factor receptor 1 and tumor necrosis factor receptor 2 gene polymorphisms and serum levels with periodontitis and type 2 diabetes in Serbian population (2020) Archives of Oral Biology, 120, art. no. 104929.  DOI: 10.1016/j.archoralbio.2020.104929
    31. Sljivancanin Jakovljevic, T., Jacimovic, J., Nikolic, N., Milasin, J. Lack of association between glutathione S-transferase M1 and T1 gene polymorphisms and susceptibility to preeclampsia: An updated systematic review and meta-analysis (2020) American Journal of Reproductive Immunology, 84 (6), art. no. e13303. DOI: 10.1111/aji.13303
    32. Sljivancanin Jakovljevic, T., Kontic-Vucinic, O., Nikolic, N., Carkic, J., Milasin, J. VAL158MET catechol O-methyltransferase polymorphism contributes to the development of preeclampsia (2020) Hypertension in Pregnancy, 39 (4), pp. 471-480. DOI: 10.1080/10641955.2020.1843663
    33. Jakovljevic, A., Nikolic, N., Jacimovic, J., Pavlovic, O., Milicic, B., Beljic-Ivanovic, K., Miletic, M., Andric, M., Milasin, J. Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020 (2020) Journal of Endodontics, 46 (10), pp. 1371-1386.e8. DOI: 10.1016/j.joen.2020.07.007
    34. Carkic, J., Nikolic, N., Nisevic, J., Lazarevic, M., Kuzmanovic-Pficer, J., Jelovac, D., Milasin, J. Endothelial nitric oxide synthase polymorphisms/haplotypes are strong modulators of oral cancer risk in serbian population (2020) Journal of Oral Science, 62 (3), art. no. josnusd/19-0310, pp. 322-326. DOI: 10.2334/josnusd.19-0310
    35. Jakovljevic, A., Nikolic, N., Carkic, J., Beljic-Ivanovic, K., Soldatovic, I., Miletic, M., Andric, M., Milasin, J. Association of polymorphisms in TNF-α, IL-1β, GSTM and GSTT genes with apical periodontitis: is there a link with herpesviral infection? (2020) International Endodontic Journal, 53 (7), pp. 895-904. DOI: 10.1111/iej.13298
    36. Vučković, M., Nikolić, N., Milašin, J., Đorđević, V., Milinković, I., Asotić, J., Jezdić, Z., Janković, S., Aleksić, Z. The effect of injectable platelet-rich fibrin use in the initial treatment of chronic periodontitis (2020) Srpski Arhiv za Celokupno Lekarstvo, 148 (5-6), pp. 280-285. DOI: 10.2298/SARH190925022V
    37. Mijailovic, I., Nikolic, N., Djinic, A., Carkic, J., Milinkovic, I., Peric, M., Jankovic, S., Milasin, J., Aleksic, Z. The down-regulation of Notch 1 signaling contributes to the severity of bone loss in aggressive periodontitis (2020) Journal of Periodontology, 91 (4), pp. 554-561. DOI: 10.1002/JPER.18-0755
    38. Dragovic, M., Pejovic, M., Stepic, J., Colic, S., Dozic, B., Dragovic, S., Lazarevic, M., Nikolic, N., Milasin, J., Milicic, B.Comparison of four different suture materials in respect to oral wound healing, microbial colonization, tissue reaction and clinical features—randomized clinical study(2020) Clinical Oral Investigations, 24 (4), pp. 1527-1541. DOI: 10.1007/s00784-019-03034-4
    39. Jakovljevic, A., Nikolic, N., Carkic, J., Andric, M., Miletic, M., Beljic-Ivanovic, K., Jovanovic, T., Milasin, J. Notch–a possible mediator between Epstein-Barr virus infection and bone resorption in apical periodontitis (2020) Acta Odontologica Scandinavica, 78 (2), pp. 126-131. DOI: 10.1080/00016357.2019.1658896
    40. Andjus, S., Lazović, V., Nikolić, N., Tubić, B., Nikolić, V., Paunović, M. Distribution of freshwater sponges in Serbia (2020) Fundamental and Applied Limnology, 193 (3), pp. 195-204. DOI: 10.1127/fal/2019/1242
    41. Andjus, S., Nikolic, N., Marjanovic, A., Brankovic, M., Lazovic, V., Tubić, B., Čanak Atlagić, J., Nikolić, V., Paunović, M. First record of freshwater sponge Trochospongilla horrida Weltner, 1893 in Serbia – A morphological and genetic study (2019) Limnologica, 76, pp. 48-51. DOI: 10.1016/j.limno.2019.03.004
    42. Sljivancanin Jakovljevic, T., Kontic-Vucinic, O., Nikolic, N., Carkic, J., Soldatovic, I., Milasin, J. Glutathione-S-transferase M1 polymorphism and pro-inflammatory cytokines tumour necrosis factor-α and interleukin-1β are associated with preeclampsia in Serbian women (2019) American Journal of Reproductive Immunology, 81 (5), art. no. e13105. DOI: 10.1111/aji.13105
    43. Jakovljevic, A., Miletic, M., Nikolic, N., Beljic-Ivanovic, K., Andric, M., Milasin, J. Notch signaling pathway mediates alveolar bone resorption in apical periodontitis (2019) Medical Hypotheses, 124, pp. 87-90. DOI: 10.1016/j.mehy.2019.02.018
    44. Nikolic, N., Jakovljevic, A., Carkic, J., Beljic-Ivanovic, K., Miletic, M., Soldatovic, I., Andric, M., Ivanovic, V., Milasin, J. Notch Signaling Pathway in Apical Periodontitis: Correlation with Bone Resorption Regulators and Proinflammatory Cytokines (2019) Journal of Endodontics, 45 (2), pp. 123-128. DOI: 10.1016/j.joen.2018.10.015
    45. Simonović, J., Toljić, B., Rašković, B., Jovanović, V., Lazarević, M., Milošević, M., Nikolić, N., Panajotović, R., Milašin, J. Raman microspectroscopy: Toward a better distinction and profiling of different populations of dental stem cells (2019) Croatian Medical Journal, 60 (2), pp. 78-86. DOI: 10.3325/cmj.2019.60.78